Cardiovascular and Metabolic Adverse Reactions Associated with the Use of Antipsychotic Drugs: A Narrative Review
Published: January 1, 2022 | DOI: https://doi.org/10.7860/JCDR/2022/51370.15911
Priya C Patel, Preeti L Navik, Manish J Barvaliya, Tejas K Patel, Hemangi A Virani
1. Resident, Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.
2. Resident, Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.
3. Assistant Professor, Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.
4. Associate Professor, Department of Pharmacology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
5. Resident, Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.
Correspondence
Dr. Preeti L Navik,
Resident, Department of Pharmacology, Government Medical College,
Bhavnagar, Gujarat, India.
E-mail: drpreetinavik@gmail.com
The adverse drug reaction profile of antipsychotic drugs includes neurological, endocrinal anticholinergic and cardiovascular effects. The profile of each cardiovascular adverse effects, specific for each antipsychotic medication includes QT prolongation, orthostatic hypotension, myocarditis and metabolic effects, it also reduce the life expectancy of schizophrenic patients. There is a major clinical concern for the patients on long term therapy. This narrative review is focused on the cardiovascular profile of antipsychotic medications. The detailed aetiology, mechanism, monitoring and management of cardiovascular adverse effects are discussed in this review.
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